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This study investigates the thermal and mechanical properties of Isua clay to assess its suitability for industrial applications, particularly in refractory and structural materials. The research involves systematic sampling and laboratory analysis to determine key parameters such as refractoriness, thermal conductivity, thermal shock resistance, compressive strength, modulus of rupture, and Mohs hardness. The results indicate that Isua clay has a refractoriness of 28 PCE (~1650°C), a thermal conductivity of 0.85 W/mK, and a thermal shock resistance of 32 cycles at 1200°C, positioning it as a viable candidate for high-temperature applications. Additionally, the mechanical tests reveal a compressive strength of 12.4 MPa, a modulus of rupture of 6.8 MPa, and a Mohs hardness of 3, indicating good structural integrity and moderate wear resistance. Comparative analysis with other Nigerian clays such as Kankara, Edda, Nsu, and Ubakala clays highlights Isua clay's competitive thermal and mechanical performance. The findings suggest that Isua clay is suitable for refractory applications, including furnace linings, ceramic production, and metallurgical processes, with potential for optimization through beneficiation and additive incorporation.