• 2020-11-10
• Oladimeji A.O, Karigidi K.O
• Volume 2, Issue 2

Abstract

Medicinal plants have been used since time immemorial for treatment and management of diseases. This work sought to investigate the phytochemical present and hypoglycemic ability of Nauclea latifolia and Spondia mombin extracts in alloxan-induced diabetes. Diabetic was induced by single intraperitoneal injection of alloxan monohydrate (100mg/kg). Normal and diabetic rats were divided into seven groups to receive different doses of Nauclea latifolia and Spondia mombin extracts for twenty-eight days. The hypoglycemic effects were monitored on blood glucose and oral glucose tolerance test (OGTT). Phytochemical screening of the extracts showed the presence of tannins, steroid, resin, phenol, glycoside, flavonoid and cardiac glycoside. The extracts were able to significantly (p< 0.05) lower the blood glucose level and improved the OGTT of the diabetic rats. Therefore, it could be concluded that extracts of Nauclea latifolia and Spondia mombin possess antihyperglycemic agent which could be used in the management of diabetes mellitus.

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